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AstraZeneca PLC (AZN) Fair Value & Analysis

Healthcare · US · Market cap $271B

AP AstraZeneca PLC logo AstraZeneca PLC AZN · US
Price$157.24
Fair Value$127.32
Upside-19.0%
Quality69/100
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Healthy Growth
Solidly profitable · 17.2% net margin
Moderate debt · generates free cash flow
1.80% dividend yield
Ranks above peers (9/15)
Wide moat 82/100
Evidence: High Range $72.51 – $172.84 Share as image

Fair value as of: Aug 14, 2026

From 24 valuation models · updated today

Fair value updated Aug 14, 2026, revised from $129.54 to $127.32 (−1.7%) since Jul 14, 2026. Share price −4.4% over the past month.

A solid business, but screening 19% overvalued on our models.

What matters now

  • Solid but not exceptional quality (69/100) and above fair value, neither a clear bargain nor a standout compounder.
  • A fairly wide model range ($72.51 to $172.84) leaves room in how you read the outcome.
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Price vs Fair Value (5 years)

$208.45 $97.38 Fair Value $127.32 May 2021 Aug 2026

White line = price, green steps = our fair value per fiscal year, dashed = 300-day average. As of Aug 14, 2026.

How to read this chart

60‑month range $97.38 – $208.45 · fair‑value band $72.51 – $172.84 · the $157.24 price screens above the $127.32 fair value. Green steps = our fair value per fiscal year (point-in-time, no hindsight). Dashed = 300-day average. As of Aug 14, 2026.

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Analysis

AstraZeneca PLC (AZN) currently trades at $157.24, while our model-based Fair Value estimate is $127.32, implying the stock looks roughly 19.0% overvalued today. The Quality Score stands at 69/100 (solid quality), in the Healthcare sector. Bear case: priced above our estimate, the market already discounts strong expectations. Bull case: above-average quality can justify a premium, the entry price still matters most (evidence: high).

Over the trailing twelve months, AstraZeneca PLC generated revenue of $60.4B at a net margin of 17.2%. Revenue grew 12.5% year over year. It earns a return on equity of 23.5%. Net debt stands at $24.0B. Fundamentals as of Aug 14, 2026

Our scenario range runs from $72.51 (bear case) to $172.84 (bull case); at $157.24, the current price sits within that range. Bear and bull are the same models run on conservative and optimistic assumptions (margins, growth, valuation multiples), so a plausible valuation range, not a price target. The share trades about 25% below its 52-week high and 17% above its 52-week low, currently below its 200-day average. For context, the median of 10 Healthcare peers we cover trades at -16% fair-value upside, at -19%, AZN screens richer than that median.

Fair Value models

Each model estimates fair value its own way; the Fair Value above is the evidence-weighted blend. Evidence (0–100) measures how completely this model’s inputs are available: well-fed models carry more weight in the blend. The spread across models is intentional, each one stresses a different value driver; dividend models, for instance, come out structurally low when payout is small.

Model Bear Bear = the cautious scenario: the same model computed with conservative anchors (lower growth, margins and valuation multiples). Together with Bull it frames a plausible valuation range, not a price target.BaseBull Bull = the optimistic scenario: the same model computed with favourable anchors (higher growth, margins and valuation multiples). Together with Bear it frames a plausible valuation range, not a price target. Evidence
Highest evidence
Growth DCF $56.40 $92.61 $147.39 80
Residual Income $45.00 $59.77 $268.71 76
Rev-Margin DCF $60.91 $107.93 $162.14 74
All 24 models by family
DCF Models
FCF DCF $55.05 $95.79 $161.41 38
Owner Earnings $66.02 $113.40 $189.72 31
5Y Revenue Exit $60.91 $108.25 $169.04 39
5Y EBITDA Exit $88.67 $160.41 $244.76 41
5Y P/E Exit $75.12 $134.96 $198.10 38
10Y Revenue Exit $55.74 $99.28 $158.44 36
10Y EBITDA Exit $76.43 $136.42 $217.83 37
10Y P/E Exit $67.58 $118.30 $181.23 35
Earnings-Based
Graham-Dodd $44.96 $142.76 $190.24 54
Lynch FV $31.43 $44.90 $58.37 50
PEG = 1.0 $31.43 $44.90 $58.37 46
EPV $62.38 $75.55 $87.25 59
Multiples
P/E Multiple $109.11 $145.47 $181.84 63
P/S Multiple $84.31 $112.41 $140.51 58
P/B Multiple $84.31 $112.41 $140.51 55
EV/EBIT $100.73 $138.39 $176.05 53
EV/EBITDA $119.61 $163.56 $207.51 54
EV/Revenue $67.28 $101.37 $135.46 43
Asset-Based
NCAV (Graham) $15.69 $21.03 $31.38 50
Growth DCF
Growth DCF $56.40 $92.61 $147.39 80
Rev-Margin DCF $60.91 $107.93 $162.14 74
Economic Profit
Residual Income $45.00 $59.77 $268.71 76
ROIC Compounder $68.12 $91.69 $120.52 72
Growth Earnings
Growth-Adj P/E $90.39 $129.13 $167.87 68

Widest divergence: Growth Earnings ($129.13) versus Asset-Based ($21.03). Highest evidence: Growth DCF (80).

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Key figures & financial health

Revenue (TTM) $60.4B
Revenue growth (YoY) +12.5%
Net margin 17.2%
Return on equity 23.5%
Free cash flow $8.7B FY2025
P/E ratio 23.6
More key figures
Operating margin 27.9%
EPS (TTM) $6.65
Dividend yield 1.8%
EPS growth (YoY) +5.3%
Net debt $24.0B FY2025

Figures from reported company fundamentals · as of Aug 14, 2026. TTM = trailing twelve months.

Quality Score breakdown

Overall quality 69/100

Of which business quality 65 · Market factors (momentum, volatility) 49

Profitability 63
Margins and returns on capital today
Quality Growth 65
Are margins and returns improving?
Cashflow 63
Earnings quality: real cash, not paper profit
Fin. Strength 60
Balance sheet, leverage, solvency risk
Investment 60
Disciplined investing over empire-building
Low Volatility 85
Calm price path (market factor)
Momentum 32
Price trend over the last 3–12 months (market factor)
52W Momentum 36
Distance to the 52-week high (market factor)
Net Issuance 82
Buybacks instead of dilution

Non-valuation factor families (profitability, growth, cashflow, financial strength, momentum …), each academically grounded. Valuation itself sits in the Fair Value and is deliberately excluded here to avoid double-counting.

About the company

AstraZeneca PLC, a biopharmaceutical company, focuses on the discovery, development, manufacture, and commercialization of prescription medicines.

Full company description

AstraZeneca PLC, a biopharmaceutical company, focuses on the discovery, development, manufacture, and commercialization of prescription medicines. The company offers Imjudo, Datroway, Iressa, Tagrisso, Imfinzi, Lynparza, Calquence, Enhertu, Orpathys, Truqap, Zoladex, Faslodex, Crestor, Andexxa, Onglyza, Symlin, XIGDUO XR, Atacand, Atacand HCT, Atacand Plus, Farxiga/Forxiga, Plendil, Modip, Splendil, Munobal, Flodil, Tenormin, Tenormine, Prenormine, Atenol, Zestril, Brilinta/Brilique, Komboglyze, Qtern, Wainua, Byetta, Lokelma, Seloken ZOK, Toprol-XL, Betaloc ZOK, XIGDUO, Accolate, Accoleit, Vanticon, Bricanyl Respules, Eklira Genuair/Tudorza/Bretaris, Pulmicort Turbuhaler, Symbicort Turbuhaler, Airsupra, Bricanyl Turbuhaler, Fasenra, Rhinocort, Tezspire, Bevespi Aerosphere, Daliresp/Daxas, Oxis Turbuhaler, Saphnelo, Breztri Aerosphere, Duaklir Genuair, Pulmicort Respules, and Symbicort pMDI. It also provides Beyfortus, Kavigale, Evusheld, Fluenz/FluMist, Synagis, Kanuma, Ultomiris, Koselugo, Voydeya, Soliris, Strensiq, Nexium, and other medicines. The company offers its products for ocology, cardiovascular, renal and metabolism, respiratory & immunology, vaccines and immune, and therapies rare diseases. It serves primary and specialty care physicians through distributors and local representative offices in the United Kingdom, the Americas, rest of Europe, Asia, Africa, and Australasia. It has a strategic agreement with Tempus and Pathos to develop the largest multimodal foundation model in oncology; CSPC Pharmaceutical Group Limited to advance the discovery and development of novel oral candidates, with the potential to treat diseases across multiple indications; and Nucs AI Inc. to develop AI-driven Response Prediction for Therapeutic Radioconjugates. The company was formerly known as Zeneca Group PLC and changed its name to AstraZeneca PLC in April 1999. AstraZeneca PLC was incorporated in 1992 and is headquartered in Cambridge, the United Kingdom.

Company description, as reported by the company or data provider.

Revenue & earnings trend

FY2021 – FY2025 · reported fiscal years

AstraZeneca PLC reported revenue of $58.7B in FY2025 versus $37.4B in FY2021, a compound +11.9%/yr. Reported net income was $10.3B in FY2025, compounding +209.3%/yr from FY2021.

Growth Quality 100/100
Revenue growth appears healthy and is supported by profitability and cash-flow quality.
Latest Revenue (FY 2025)
$58.7B
Latest YoY
+8.6%
Avg. growth/yr (3Y) Measures the company's TOTAL revenue from reported annual statements: compound average growth per year (CAGR) from the fiscal year 3, 5 or N years back to the most recent comparable fiscal year. Not per share: buybacks do not change this number, and a merger can appear as a growth jump.
+9.8%
Avg. growth/yr (5Y) Measures the company's TOTAL revenue from reported annual statements: compound average growth per year (CAGR) from the fiscal year 3, 5 or N years back to the most recent comparable fiscal year. Not per share: buybacks do not change this number, and a merger can appear as a growth jump.
+17.2%
Avg. growth/yr (35Y) Measures the company's TOTAL revenue from reported annual statements: compound average growth per year (CAGR) from the fiscal year 3, 5 or N years back to the most recent comparable fiscal year. Not per share: buybacks do not change this number, and a merger can appear as a growth jump.
+6.1%
Revenue +11.9%/yr
FY21 $37.4B
FY22 $44.4B
FY23 $45.8B
FY24 $54.1B
FY25 $58.7B
Net income +209.3%/yr
FY21 $112M
FY22 $3.3B
FY23 $6.0B
FY24 $7.0B
FY25 $10.3B
Character of growth · EPS growth decomposed (2014-2025) +10.7 % p.a.
Revenue per share +6.3 pp

of which total revenue +8.8 pp · buybacks/dilution −2.5 pp

EBIT margin +3.3 pp
Tax rate −1.5 pp
Residual (interest, one-offs) +2.6 pp

Absolute contributions in percentage points per year; they sum to the EPS growth rate. Start and end points are 3-year averages (details on hover).

AZN screens 19% overvalued. Compare with Eli Lilly and Company →

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Cite: Fair Value Calculator (2026). "AstraZeneca PLC Fair Value". https://www.fairvalue-calculator.com/stock/AZN

Recent news

External third-party headlines (Yahoo Finance, Reuters and others), not an editorial selection.

Peer Group

Drug Manufacturers - General · 77 stocks

How this stock ranks against its industry: the green marker is this stock, the band is the typical 25–75% peer range, and the tick is the median.

Quality Score 69 · Above median
Fair Value upside −19% · Above median
Return on equity (TTM) 23% · Above median
Return on assets 8% · Above median
Net margin (TTM) 17% · Above median
Operating margin (TTM) 28% · Above median
Revenue growth 13% · Above median
Dividend yield (TTM) 1.8% · Below median
Debt / equity 0.51× · Higher than 75% of peers

Valuation Multiples vs Drug Manufacturers - General median · lower = cheaper

P/E (TTM) 23.6× · Pricier than median
P/B 5.58× · Pricier than median
P/S (TTM) 4.49× · Pricier than median
P/FCF 31.3× · Pricier than 75% of peers
EV/EBITDA 14.5× · Cheaper than median
PEG 1.36× · Cheaper than median

Snowflake

Five quick dimensions, each 0 to 100: VALUE (fair-value potential), FUTURE (revenue growth), PAST (return on equity), HEALTH (low debt), DIVIDEND (yield). Green = this stock, grey = typical sector peer.

VALUE 8 · sector 0
FUTURE 63 · sector 25
PAST 94 · sector 49
HEALTH 75 · sector 94
DIVIDEND 36 · sector 44

Values & ESG

Does this company touch areas you may want to avoid? The classification is inferred from sector and industry.

None of the checked exposures detected

ESG scores are not available for this stock yet. Values and ESG data are contextual and can differ between providers.

Similar stocks

10 more Drug Manufacturers - General stocks, each showing price versus our Fair Value estimate (as of Aug 14, 2026).

Stock Price Fair Value vs Fair Value
Eli Lilly and Company LLY $1,220 $389.47 -68%
Johnson & Johnson, JNJ $260.86 $169.04 -35%
AbbVie Inc ABBV $248.76 $67.72 -73%
Roche Holding 1RO €392.80 €240.14 -39%
Merck & Co MRK €115.42 €118.21 +2%
Novartis AG NVSN 2,742 MXN 1,964 MXN -28%
Novo Nordisk A/S NOVOB kr 299.50 kr 409.46 +37%
Sanofi SNYN 770.00 MXN 1,041 MXN +35%
GSK plc GSKN 917.00 MXN 879.08 MXN -4%
Bayer Aktiengesellschaft BAYER 17,685 HUF 14,810 HUF -16%

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Frequently asked questions

Is AstraZeneca PLC (AZN) overvalued or undervalued?
As of Aug 14, 2026, our model estimates a fair value of $127.32 versus a price of $157.24, about −19% (overvalued).
What is the fair value of AZN?
Our model-based fair value for AstraZeneca PLC is $127.32 (as of Aug 14, 2026), built from audited fundamentals. The current price is $157.24.
What is the quality score of AZN?
AstraZeneca PLC has a Quality Score of 69/100. It measures business quality (profitability, growth, cash flow, balance-sheet strength, investment discipline, share issuance). Market factors such as price momentum and volatility do not enter the number; they are shown separately in the detail view.
What is the revenue of AstraZeneca PLC (AZN)?
AstraZeneca PLC reported trailing-twelve-month revenue of about $60.4B (latest available figure, as of Aug 14, 2026).
What is the net profit margin of AZN?
The net profit margin of AstraZeneca PLC is about 17.2%, meaning it keeps roughly 17.2% of revenue as net income. Based on the latest reported figures.
Does AstraZeneca PLC pay a dividend?
AstraZeneca PLC currently shows a dividend yield of about 1.80% relative to its recent price (as of Aug 14, 2026).

How we calculate Fair Value

Each company is valued through a stack of independent intrinsic-value models (DCF variants, residual-income, multiples and more), blended into one family-balanced consensus and weighted by how much trustworthy data backs it. A separate quality layer scores the fundamentals. Every input is real reported data, nothing guessed.

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